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Proceedings Paper

Improved quantification of chromophore concentrations in near infrared spectroscopy using prior knowledge
Author(s): Sabine Van Huffel
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Paper Abstract

Three ways are explored to improve the accuracy of currently used Near InfraRed Spectroscopy algorithms, based on the Beer-Lambert law, for quantification of chromophore concentration changes in living tissues. Therefore, new two- steps models are developed in which the estimates obtained in the first step are refined in the next step with the use of prior knowledge. In particular, when certain chromophore concentration changes are assumed to be small or in chemical equilibrium it is shown that these models can considerably improve the accuracy of the computed concentration changes of Hb, HbO2, Cytaa3, and Icg, if present, compared to the conventional least squares regression based algorithm.

Paper Details

Date Published: 1 January 1998
PDF: 10 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301093
Show Author Affiliations
Sabine Van Huffel, Katholieke Univ. Leuven (Belgium)


Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron; Britton Chance; Marco Ferrari, Editor(s)

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