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Proceedings Paper

Quantitative detection of hemoglobin saturation on piglet brain by near-infrared frequency-domain spectroscopy
Author(s): Congwu Du; Carol Andersen; Britton Chance
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Paper Abstract

An approach of using phase modulation spectroscopy (PMS) system has been proposed which has single frequency, dual- wavelength with phase-only output for oximetry to minimize the influences of room light in the clinical environment. The availability of this method has been verified by laboratory experiments both in vitro and in vivo. In this study, a 200 Mhz PMS system has been used for measuring on piglet brain in vivo, to detect blood volume and saturation change during normoxia to hypoxia periods, and to monitor the brain depolarization in the hypoxic stress. Our experimental results show that the brain saturation estimated by PMS is approximately 84% and lies between arterial and venous blood values of 97% and 80% in normoxia, and tends to move close to the venous side in hypoxia. In addition, the excessive hypoxic stress triggers the brain to be bio-energetic deficits and finally introduced the neural depolarization, which can be effectively detected by recording the increment of tissue scattering.

Paper Details

Date Published: 1 January 1998
PDF: 8 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301089
Show Author Affiliations
Congwu Du, Univ. of Pennsylvania and Carnegie Mellon Univ. (United States)
Carol Andersen, Allegheny Univ. of Health Sciences (United States)
Britton Chance, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron; Britton Chance; Marco Ferrari, Editor(s)

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