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Proceedings Paper

Near-infrared spectroscopy of the human brain: effects of apnea and hypercapnia on the intensity and phase of backscattered light
Author(s): Nicola Rosato; Fabrizio Vernieri; Francesco Tibuzzi; Francesco Passarelli; Alessandro Finazzi Agro; Paolo Maria Fasella; Flavia Pauri; Paolo Maria Rossini
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Paper Abstract

The effects of hypercapnia on the intensity and phase of near infrared light back-scattered by the head were studied on eight healthy humans and two patients affected by monohemispheric lesions in the Middle Cerebral Artery (MCA) territory. A decrease in the light intensity and a variation of the phase were detected in all healthy subjects during apnea and hypercapnia. Only negligible changes were observed in the affected hemisphere of the patients. A concomitant study by Transcranial Doppler Sonography (TCD) showed an increase of the blood flow during hypercapnia both in normal hemispheres and, to a less extent, in the affected hemisphere of patients. This suggests that NIRS (Near Infrared Spectroscopy) is more sensitive to alterations of more cortical brain vascular system than TCD which is mainly testing MCA in the depth.

Paper Details

Date Published: 1 January 1998
PDF: 8 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301080
Show Author Affiliations
Nicola Rosato, Univ. di Roma (Italy) and IRCCS (Italy)
Fabrizio Vernieri, Ospedale Fatebenefratelli (Italy)
Francesco Tibuzzi, Univ. di Roma (Italy)
Francesco Passarelli, Ospedale Fatebenefratelli (Italy)
Alessandro Finazzi Agro, Univ. di Roma (Italy) and IRCCS (Italy)
Paolo Maria Fasella, Univ. di Roma (Italy)
Flavia Pauri, Ospedale Fatebenefratelli (Italy)
Paolo Maria Rossini, Ospedale Fatebenefratelli (Italy)


Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron; Britton Chance; Marco Ferrari, Editor(s)

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