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Proceedings Paper

OCT images of human skin
Author(s): Herman Brunner; Razvan Lazar; Ralf Seschek; Thomas H. Meier; Rudolf W. Steiner
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Paper Abstract

The aim of this research is the investigation and improvement of the possibilities of optical coherence tomography (OCT) for evaluation and imaging of dermal lesions, such as melanoma. Single point detection, as done with fiber arrangements using photomultiplier for measurements on human eyes was not successful in reaching high resolutions in strongly scattering media as human skin. The maximum scanning depth was about 500 micrometers . For this reason, a new system with a wide area detection was developed. The experimental set-up consists of a highly sensitive slow-scan CCD-camera and a suitably adapted interferometric arrangement. Measurements were performed on a model made of scattering material with simple objects embedded. They show that images appear to be blurred as a consequence of the wide area detection which allows an increased measuring depth. These investigations lead to a new method for the improvement of the OCT images which is explained and demonstrated on measurements performed on the model. Measurements on preserved specimen of human skin up to a scanning depth of 2 mm are shown in comparison to corresponding histological slides to demonstrate the spatial resolution and the ability of optical coherence methods to distinguish structures with different optical parameters.

Paper Details

Date Published: 1 January 1998
PDF: 7 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301058
Show Author Affiliations
Herman Brunner, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Razvan Lazar, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Ralf Seschek, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Thomas H. Meier, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)
Rudolf W. Steiner, Institut fuer Lasertechnologien in der Medizin und Messtechnik/Univ. Ulm (Germany)


Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron M.D.; Britton Chance; Marco Ferrari, Editor(s)

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