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Proceedings Paper

Quantitation methods for determining the intrinsic composition of breast tissue in vivo using near-infrared transillumination
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Paper Abstract

We have measured transillumination spectra collected at various sites on the breasts of normal subjects. The absolute concentration of hemoglobin, lipids and water are derived using ratiometric methods. The lipids and deoxyhemoglobin signals overlap at 760 nm; the accurate separation of these thus requires explicit account to be taken of the diffusion of photons through the breast. The concentrations of Hb, lipids and water vary substantially from site to site, which will influence wavelength selection in imaging systems. Finite element calculations and solid phantom measurements demonstrate that this variability is not due to boundary effects. The spatial variation of (mu) a at wavelengths 720 nm, 820 nm, 930 nm and 970 nm is illustrated schematically. It is noted that (mu) a at 930 nm shows the least heterogeneity amongst the 8 normal subjects studied.

Paper Details

Date Published: 1 January 1998
PDF: 9 pages
Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); doi: 10.1117/12.301054
Show Author Affiliations
Steven J. Matcher, Univ. of Exeter (United Kingdom)
Valentina Quaresima, Univ. degli Studi dell'Aquila (Italy)
Marco Ferrari, Univ. degli Studi dell'Aquila (Italy)

Published in SPIE Proceedings Vol. 3194:
Photon Propagation in Tissues III
David A. Benaron; Britton Chance; Marco Ferrari, Editor(s)

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