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Proceedings Paper

Gd-DTPA-enhanced magnetic resonance imaging (MRI) for the follow-up of laser-induced thermotherapy (LITT): trial to determine a useful examination schedule
Author(s): Christoph-Thomas Germer; Christoph Martin Isbert; Dirk Albrecht; Joerg-Peter Ritz; Andreas Schilling; Andre Roggan; Karl Juergen Wolf; Gerhard J. Mueller; Heinz-Johannes Buhr
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Paper Abstract

Purpose: To evaluate gadolinium-DTPA-enhanced MRI for follow-up monitoring of laser-induced thermotherapy (LITT) and to determine of a useful examination schedule. Materials and Methods: LITT Of the liver was performed in 55 rabbits using a Nd:YAG laser (4 w power output, 840 s exposure time). Gd-DTPA MRI and histological examinations were performed at different times (0 - 168 days). Results: Laser- induced lesions underwent regeneration and volume size reduction (69% after 168 days). The correlation coefficient (MR vs macroscopic analysis) for the mean lesion diameter was r equals 0.96. Histology of lesions comprised the four zones that correlated best with MRI findings. Coagulation necroses immediately after LITT were seen as an area of no enhancement on Gd-DTPA MRI. Circular enhancement was first seen 72 - 96 hours after LITT, which was due to early mesenchymal proliferation. Conclusions: Gd-DTPA MRI is a good monitoring procedure for LITT. MRI should be performed 24 and 96 hours after LITT.

Paper Details

Date Published: 19 January 1998
PDF: 9 pages
Proc. SPIE 3193, Photothermal Therapies in Medicine, (19 January 1998); doi: 10.1117/12.300826
Show Author Affiliations
Christoph-Thomas Germer, Freie Univ. Berlin (Germany)
Christoph Martin Isbert, Freie Univ. Berlin (Germany)
Dirk Albrecht, Freie Univ. Berlin (Germany)
Joerg-Peter Ritz, Freie Univ. Berlin (Germany)
Andreas Schilling, Freie Univ. Berlin (Germany)
Andre Roggan, Freie Univ. Berlin (Germany)
Karl Juergen Wolf, Freie Univ. Berlin (Germany)
Gerhard J. Mueller, Freie Univ. Berlin (Germany)
Heinz-Johannes Buhr, Freie Univ. Berlin (Germany)

Published in SPIE Proceedings Vol. 3193:
Photothermal Therapies in Medicine
Gaetano Bandieramonte; Stephen G. Bown; Fausto Chiesa; Jacques Donnez M.D.; Herbert J. Geschwind M.D.; Gian Francesco Lombard M.D.; Gerhard J. Mueller; Hans-Dieter Reidenbach, Editor(s)

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