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Proceedings Paper

Experimental study and first clinical results with a cooled applicator system for LITT
Author(s): Verena Knappe; Andre Roggan; Martin G. Mack; Thomas J. Vogl; Dirk Albrecht; Christoph-Thomas Germer; F. Kniep; Gerhard J. Mueller
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Paper Abstract

Laser-induced interstitial thermotherapy has proven to be an effective method for the treatment of different types of tumors. Until now the attainable coagulation volume was limited by the maximum applicable energy. The limiting factor is the high tissue temperatures around the applicator which may cause applicator damage. Consequently an internally cooled catheter system has been developed in order to reduce the temperature of the applicator surface and therefore enable the application of higher laser powers. The optimal treatment parameters for the Nd:YAG laser were determined on the basis of computer simulations and in vitro studies with porcine liver. Following these experimental studies, 72 patients with liver metastases were treated with the cooled applicator system. The applicator position and the resulting tissue damage were verified using the MRI on- line monitoring system with a FLASH-2D sequence. The optimal treatment parameters were found to be 25 watts for an exposure time of 20 minutes, resulting in coagulated volumes of up to 20 cm3. The experimental and clinical results proved that the combination of a scattering laser applicator with an internally flushed catheter enables a significant increase in the coagulation volume.

Paper Details

Date Published: 19 January 1998
PDF: 11 pages
Proc. SPIE 3193, Photothermal Therapies in Medicine, (19 January 1998); doi: 10.1117/12.300822
Show Author Affiliations
Verena Knappe, Laser- und Medizin-Technologie gGmbH (Germany)
Andre Roggan, Freie Univ. Berlin (Germany)
Martin G. Mack, Strahlenklinik Rudolf Virchow Klinik/Humboldt Univ. zu Berlin (Germany)
Thomas J. Vogl, Strahlenklinik Rudolf Virchow Klinik/Humboldt Univ. zu Berlin (Germany)
Dirk Albrecht, Universitaetsklinikum Benjamin Franklin/Freie Univ. Berlin (Germany)
Christoph-Thomas Germer, Universitaetsklinikum Benjamin Franklin/Freie Univ. Berlin (Germany)
F. Kniep, Somatex Medizintechnische Instrumente (Germany)
Gerhard J. Mueller, Laser- und Medizin-Technologie gGmbH (Germany)


Published in SPIE Proceedings Vol. 3193:
Photothermal Therapies in Medicine
Gaetano Bandieramonte; Stephen G. Bown; Fausto Chiesa; Jacques Donnez; Herbert J. Geschwind; Gian Francesco Lombard; Gerhard J. Mueller; Hans-Dieter Reidenbach, Editor(s)

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