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Proceedings Paper

Computer simulation model of tumor treatment: fractionated irradiation
Author(s): Alexei A. Ivankov
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Paper Abstract

A new stochastic model of tumor growth is developed. The main goal of the investigation is to get some estimates of observable and unobservable parameters of tumor growth process under given assumptions of malignant cell behavior. The model allows to come over some difficulties encountered in reaching the above-mentioned goal by methods of stochastic branching processes theory, i.e. if the independence hypothesis is not valid. The principal phenomena of cellular level were taken into account to simulate cell population development: cell proliferation, reproduction, reproductive type of cell death and apoptosis. The model allows as well to simulate tumor treatment: radiotherapy and/or drug administration. The treatment is considered as a stochastic process of damage accumulation and reparation into malignant cell. This approach to biological phenomena modeling is extremely fruitful to test statistical hypothesis on the nature and mechanisms of tumor growth, in particular, on tumor growth latency.

Paper Details

Date Published: 1 January 1998
PDF: 5 pages
Proc. SPIE 3345, International Workshop on New Approaches to High-Tech Materials: Nondestructive Testing and Computer Simulations in Materials Science and Engineering, (1 January 1998); doi: 10.1117/12.299617
Show Author Affiliations
Alexei A. Ivankov, St. Petersburg State Technical Univ. (Russia)


Published in SPIE Proceedings Vol. 3345:
International Workshop on New Approaches to High-Tech Materials: Nondestructive Testing and Computer Simulations in Materials Science and Engineering
Alexander I. Melker, Editor(s)

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