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Proceedings Paper

New developments in fluorescence detection of ALA-induced protoporphyrin IX for cancer localization
Author(s): Herbert G. Stepp; Reinhold Baumgartner; Christian Betz; Karl Bise; P. Brand; Fernando Gamarra; Karl Haeussinger; Peter Hillemanns; Rudolf M. Huber; Ruth Knuechel; M. Kriegmair; Andreas Leunig; J. Pichler; Kai Rick; H. Schulz; F. Stanzel; Susanne Stocker; Simon Wagner; H. Weigandt
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Paper Abstract

After the very promising clinical results for the detection of bladder cancer in urology, preclinical and clinical studies on aminolevulinic acid (5-ALA) induced protoporphyrin IX (PPIX) are preformed in various disciplines now. This paper provides a brief overview of the progress on 5-ALA assisted fluorescence diagnosis in urology, pulmonology, neurosurgery, gynecology and ENT performed in collaboration with the Laser Research Laboratory at the Department of Urology of the Ludwig-Maximilians-University in Munich. Five-ALA can be applied either topically or systemically to induce an intracellular accumulation of fluorescing PPIX. With appropriate dosage of 5-ALA, malignant tissue can be stained selectively, and irradiation with violet light excites a bright red fluorescence of the tumor. Optical properties of the tissue tend to hamper the precise identification and demarcation of suspect areas in fluorescence images. Multicolor remission and fluorescence imaging, therefore, seems to be indispensable for a reliable tumor localization.

Paper Details

Date Published: 29 December 1997
PDF: 7 pages
Proc. SPIE 3197, Optical Biopsies and Microscopic Techniques II, (29 December 1997); doi: 10.1117/12.297952
Show Author Affiliations
Herbert G. Stepp, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Reinhold Baumgartner, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Christian Betz, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Karl Bise, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
P. Brand, Forschungszentrum fuer Umwelt und Gesundheit (Germany)
Fernando Gamarra, Ludwig-Maximilians Univ. (Germany)
Karl Haeussinger, Landesversicherungsanstalt Unterfranken Klinikum Gauting (Germany)
Peter Hillemanns, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Rudolf M. Huber, Ludwig-Maximilians Univ. (Germany)
Ruth Knuechel, Univ. of Regensburg (Germany)
M. Kriegmair, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Andreas Leunig, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
J. Pichler, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Kai Rick, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
H. Schulz, Forschungszentrum fuer Umwelt und Gesundheit (Germany)
F. Stanzel, Landesversicherungsanstalt Unterfranken Kliniken Gauting (Germany)
Susanne Stocker, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
Simon Wagner, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)
H. Weigandt, Klinikum Grosshadern/Ludwig-Maximilians Univ. (Germany)


Published in SPIE Proceedings Vol. 3197:
Optical Biopsies and Microscopic Techniques II
Irving J. Bigio; Herbert Schneckenburger; Jan Slavik; Katarina Svanberg M.D.; Pierre M. Viallet, Editor(s)

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