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Proceedings Paper

Endoscopic OCT for in-vivo imaging of precancer and cancer states of human mucosa
Author(s): Alexander M. Sergeev; Valentin M. Gelikonov; Grigory V. Gelikonov; Felix I. Feldchtein; Roman V. Kuranov; Natalia D. Gladkova; Natalia M. Shakhova; Irina N. Kuznetzova; Ludmila Snopova; Arkady Denisenko; Valentin Almasov
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Paper Abstract

First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in gastrointestinal and genital tracts are presented. A novel endoscopic OCT system has ben created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, stomach and uterine cervix as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancerous tissue is distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

Paper Details

Date Published: 13 January 1998
PDF: 6 pages
Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); doi: 10.1117/12.297941
Show Author Affiliations
Alexander M. Sergeev, Institute of Applied Physics (Russia)
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Felix I. Feldchtein, Institute of Applied Physics (Russia)
Roman V. Kuranov, Institute of Applied Physics (Russia)
Natalia D. Gladkova, Institute of Applied Physics (Russia)
Natalia M. Shakhova, Nizhny Novgorod Medical Academy (Russia)
Irina N. Kuznetzova, Nizhny Novgorod Medical Academy (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Arkady Denisenko, Nizhny Novgorod Regional Hospital (Russia)
Valentin Almasov, Nizhny Novgorod Regional Medical Diagnostic Ctr. (Russia)

Published in SPIE Proceedings Vol. 3196:
Optical and Imaging Techniques for Biomonitoring III
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Abraham Katzir, Editor(s)

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