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Proceedings Paper

Autofluorescence of normal and neoplastic human brain tissue: an aid for intraoperative delineation of tumor resection margins
Author(s): Giovanni F. Bottiroli; Anna Cleta Croce; Donata Locatelli; Rosanna Nano; Ermanno Giombelli; Alberto Messina; Eugenio Benericetti
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Paper Abstract

Light-induced autofluorescence measurements were made on normal and tumor brain tissues to assess their spectroscopic properties and to verify the potential of this parameter for an intraoperative delineation of tumor resection margins. Spectrofluorometric analysis was performed both at the microscope on tissue sections from surgical resection, and on patients affected by glioblastoma, during surgical operation. Significant differences in autofluorescence emission properties were found between normal and tumor tissues in both ex vivo and in vivo measurements, indicating that the lesion can be distinguished from the informal surrounding tissues by the signal amplitude and the spectral shape. The non-invasiveness of the technique opens interesting prospects for improving the efficacy of neurosurgical operation, by allowing an intraoperative delimitation of tumor resection margins.

Paper Details

Date Published: 13 January 1998
PDF: 9 pages
Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); doi: 10.1117/12.297933
Show Author Affiliations
Giovanni F. Bottiroli, Univ.degli Studi di Pavia (Italy)
Anna Cleta Croce, Univ.degli Studi di Pavia (Italy)
Donata Locatelli, Univ.degli Studi di Pavia (Italy)
Rosanna Nano, Univ.degli Studi di Pavia (Italy)
Ermanno Giombelli, Azienda Ospedaliera E. Morelli (Italy)
Alberto Messina, Azienda Ospedaliera E. Morelli (Italy)
Eugenio Benericetti, Azienda Ospedaliera E. Morelli (Italy)

Published in SPIE Proceedings Vol. 3196:
Optical and Imaging Techniques for Biomonitoring III
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Abraham Katzir, Editor(s)

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