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Proceedings Paper

Tumor detection with cyanine dye poly(ethylene glycol) conjugates as contrast agents for near-infrared imaging
Author(s): Bjoern Riefke; Kai Licha; Dirk Nolte; Bernd Ebert; Herbert H. Rinneberg; Wolfhard Semmler
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Paper Abstract

The influence of the molecular weight of cyanine dye- poly(ethylene glycol) (PEG) conjugates on their pharmacokinetic behavior and on the contrast between malignant and normal tissue in fluorescence images was studied. PEG conjugates with a molecular weight ranging from 1800 to 40000 g mol-1 were investigated in a rat model. A tunable, pulsed, solid-state laser system and an intensified CCD camera served to record fluorescence images of different tumor-bearing mice and rats. The time window of increased contrast between tumor and normal tissue in fluorescence images can be adjusted by the molecular weigh of PEG residues. Furthermore, we were able to demonstrate the visualization of subcutaneous blood vessels.

Paper Details

Date Published: 13 January 1998
PDF: 8 pages
Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); doi: 10.1117/12.297924
Show Author Affiliations
Bjoern Riefke, Institut fuer Diagnostikforschung an der Freien Univ. Berlin (Germany)
Kai Licha, Institut fuer Diagnostikforschung an der Freien Univ. Berlin (Germany)
Dirk Nolte, Physikalisch-Technische Bundesanstalt (Germany)
Bernd Ebert, Physikalisch-Technische Bundesanstalt (Germany)
Herbert H. Rinneberg, Physikalisch-Technische Bundesanstalt (Germany)
Wolfhard Semmler, Freie Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 3196:
Optical and Imaging Techniques for Biomonitoring III
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D.; Abraham Katzir, Editor(s)

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