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Proceedings Paper

Synthesis and characterization of cyanine dye poly(ethylene glycol) conjugates as contrast agents for in-vivo fluorescence imaging
Author(s): Kai Licha; Bjoern Riefke; Wolfhard Semmler
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Paper Abstract

Cyanine dyes are promising near-IR contrast agents because of their high molar absorption between 700 and 1000 nm, minimal phototoxicity and convenient synthetic availability. It is known that the derivatization of drugs or contrast agents with polyethylene glycol residues leads to enhanced retention in tumor tissue. The purpose of this study was to generate indotricarbocyanines with improved pharmacological properties enabling in vivo fluorescence detection of tumors. Several hydrophilic indotricarbocyanine- poly(ethylene glycol) conjugates of different molecular weight were synthesized and characterized physicochemically and photophysically in order to test their applicability as near IR contrast media.

Paper Details

Date Published: 13 January 1998
PDF: 5 pages
Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); doi: 10.1117/12.297923
Show Author Affiliations
Kai Licha, Institut fuer Diagnostikforschung GmbH an der Freien Univ. Berlin (Germany)
Bjoern Riefke, Institut fuer Diagnostikforschung GmbH an der Freien Univ. Berlin (Germany)
Wolfhard Semmler, Institut fuer Diagnostikforschung GmbH an der Freien Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 3196:
Optical and Imaging Techniques for Biomonitoring III
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska; Abraham Katzir, Editor(s)

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