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Proceedings Paper

Application of optical diffusion theory to transcutaneous bilirubinometry
Author(s): Thorsten Spott; Lars Othar Svaasand; R. E. Anderson; P. F. Schmedling
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Paper Abstract

Neonatal hyperbilirubinemia affects more than half of the newborns and represents a potentially serious condition due to the toxicity of bilirubin to the central nervous system. A precise non-invasive technique for the monitoring of bilirubin concentration is desirable for the treatment of icteric babies. Transcutaneous bilirubinometry based on optical reflectance spectra is complicated by the superposition of the spectral absorption properties of melanin and haemoglobin with those of bilirubin. Diffusion theory forms a suitable model for the description of light propagation in tissue. In this treatment, an inverse diffusion approach is developed to measure bilirubin concentration in tissue by means of the reflectance spectrum. First results of its application to in vivo measurements are encouraging.

Paper Details

Date Published: 14 January 1998
PDF: 12 pages
Proc. SPIE 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III, (14 January 1998); doi: 10.1117/12.297907
Show Author Affiliations
Thorsten Spott, Norwegian Univ. of Science and Technology (Norway)
Lars Othar Svaasand, Norwegian Univ. of Science and Technology (Norway)
R. E. Anderson, Norwegian Univ. of Science and Technology (Norway)
P. F. Schmedling, Norwegian Univ. of Science and Technology (Norway)


Published in SPIE Proceedings Vol. 3195:
Laser-Tissue Interaction, Tissue Optics, and Laser Welding III
Guy P. Delacretaz; Guilhem Godlewski; Roberto Pini; Rudolf W. Steiner; Lars Othar Svaasand, Editor(s)

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