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Proceedings Paper

Molecular operation on elastic fibers and cholesterol ester by a free-electron laser
Author(s): Kunio Awazu; Seiji Ogino; Akio Nagai; Takio Tomimasu; Steven L. Jacques
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Paper Abstract

A method has been found to selectively ablate cholesterol esters accumulated in an arteriosclerotic region of a rabbit artery without damaging the blood vessel using a free-electron laser (FEL). A FEL is a pulsed laser source that generates a beam by amplifying the coherent radiation emitted by an electron beam that is traveling through a periodically alternating magnetic field at a relativistic velocity. The characteristics of the FEL include a broadly tunable wavelength and ultra-short pulse width. We have found that FEL irradiation of a rabbit arterial wall for 1 min with a power of 1.5 mW can ablate cholesterol esters without damaging the elastic fibers of the arterial wall. The FEL was tuned to 5.75 micrometer, which is a wavelength that is absorbed by cholesterol ester. This method may be used as a non-invasive surgical procedure for the treatment of arteriosclerotic arteries.

Paper Details

Date Published: 14 January 1998
PDF: 7 pages
Proc. SPIE 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III, (14 January 1998); doi: 10.1117/12.297906
Show Author Affiliations
Kunio Awazu, Free Electron Laser Research Institute (Japan)
Seiji Ogino, Free Electron Laser Research Institute (Japan)
Akio Nagai, Free Electron Laser Research Institute (Japan)
Takio Tomimasu, Free Electron Laser Research Institute (Japan)
Steven L. Jacques, Oregon Medical Laser Ctr. (United States)


Published in SPIE Proceedings Vol. 3195:
Laser-Tissue Interaction, Tissue Optics, and Laser Welding III
Guy P. Delacretaz; Guilhem Godlewski M.D.; Roberto Pini; Rudolf W. Steiner; Lars Othar Svaasand, Editor(s)

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