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Proceedings Paper

Comparative study of skin welding in the rat using low-power CO2 laser beam: macroscopic observations and histologic and histochemical studies using Picrosirius red stain for collagen determination
Author(s): Shamai Giler; Avraham Weinberger; Rivka Gal; Marissa Halpern
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Paper Abstract

In 50 rats, a full thickness abdominal skin incision was made with a CO2 laser (LI) (Kaplan PenduLaser 115) and in another group, an incision was made by a scalpel (SI). These groups were divided into 2 subgroups: a low power CO2 laser skin welding of 500 mw was used in LI and SI subgroups and, in the other, the wound was closed with nylon sutures. On the fourth postoperative day in the LI welding group, a complete dehiscence wound was formed in one animal and in the SI welding group, a partial dehiscence. After one week, a thin line of young (fresh) scar was observed with complete healing after 2 weeks. Histology revealed after four days, a deep cleft in the LI and SI welding groups and a superficial ulcer after one week and after two weeks, all groups showed complete healing. Histochemical studies (Picrosirius red stain) revealed in the first two weeks, greenish-yellow polarized colors and red-orange colors of a matured collagen in the well-formed scar. It appears that there was no delay in the healing process between the LI and SI groups and between welding and suture healing.

Paper Details

Date Published: 14 January 1998
PDF: 7 pages
Proc. SPIE 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III, (14 January 1998); doi: 10.1117/12.297894
Show Author Affiliations
Shamai Giler, Felsenstein Medical Research Ctr. (Israel)
Avraham Weinberger, Felsenstein Medical Research Ctr. (Israel)
Rivka Gal, Rabin Medical Ctr. (Israel) and Sackler School of Medicine/Tel Aviv Univ. (Israel)
Marissa Halpern, Rabin Medical Ctr. (Israel) and Sackler School of Medicine/Tel Aviv Univ. (Israel)


Published in SPIE Proceedings Vol. 3195:
Laser-Tissue Interaction, Tissue Optics, and Laser Welding III
Guy P. Delacretaz; Guilhem Godlewski; Roberto Pini; Rudolf W. Steiner; Lars Othar Svaasand, Editor(s)

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