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Proceedings Paper

Urethral stricture vaporization with the KTP laser provides evidence for a favorable impact of laser surgery on wound healing
Author(s): Franz R. Schmidlin; Giordano Venzi; Patrice Jichlinski; Michael Oswald; Guy P. Delacretaz; Giulio Gabbiani; Hans-Juerg Leisinger; Peter Graber
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Paper Abstract

The objective of this study was to evaluate and compare the safety and efficacy of the KTP 532 laser to direct vision internal urethrotomy (DVIU) in the management of urethral strictures. A total of 32 patients were randomized prospectively in this study, 14 DVIU and 18 KTP 532 laser. Patients were evaluated postoperatively with flowmetry and in the case of recurrence with cystourethrography at 3, 12, 24 weeks. With the KTP 532 laser complete symptomatic and uredynamic success was achieved in 15 (83%) patients at 12 and 24 weeks. Success rate was lower in the DVIU group with 9 (64%) patients at 12 weeks and 8 (57%) patients at 24 weeks. Mean preoperative peak-flow was improved from 6 cc/s to 20 cc/s at 3, 12 and 24 weeks with the KTP laser. With DVIU mean preoperative peak-flow was improved from 5.5 cc/s to 20 cc/s at 3 weeks followed by a steady decrease to 13 cc/s at 12 weeks and to 12 cc/s 24 weeks. No complication was observed in either group of patients. Our results confirm that stricture vaporization with the KTP 532 laser is a safe and efficient procedure. The better results after laser surgery make it also a valuable alternative in the endoscopic treatment of urethral strictures. These findings suggest a favorable influence of laser surgery on wound healing with less wound contraction and scarring. The lack of contraction of laser wounds might be related to the absence and the lack of organization of myofibroblasts in laser induced lesions.

Paper Details

Date Published: 22 December 1997
PDF: 4 pages
Proc. SPIE 3192, Medical Applications of Lasers in Dermatology, Ophthalmology, Dentistry, and Endoscopy, (22 December 1997); doi: 10.1117/12.297854
Show Author Affiliations
Franz R. Schmidlin, Univ. Hospital Geneva (Switzerland)
Giordano Venzi, Univ. Hospital Geneva (Switzerland)
Patrice Jichlinski, Univ. Hopsital Lausanne (Switzerland)
Michael Oswald, Univ. Hospital Lausanne (Switzerland)
Guy P. Delacretaz, Ecole Polytechnique Federale de Lausanne (Switzerland)
Giulio Gabbiani, Univ. of Geneva (Switzerland)
Hans-Juerg Leisinger, Univ. Hospital Lausanne (Switzerland)
Peter Graber, Univ. Hosptial Geneva (Switzerland)


Published in SPIE Proceedings Vol. 3192:
Medical Applications of Lasers in Dermatology, Ophthalmology, Dentistry, and Endoscopy
Gregory B. Altshuler; Reginald Birngruber; Marco Dal Fante; Raimund Hibst; Herbert Hoenigsmann; Neville Krasner; Frederic Laffitte, Editor(s)

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