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Proceedings Paper

In-vivo cataractograms using a compact backscatter dynamic light scattering (DLS) probe
Author(s): Rafat R. Ansari; Kwang I. Suh; Sparta J. Tumminia; Paul Russell; J. Samuel Zigler
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Paper Abstract

A compact fiber optic probe developed by Ansari et al. for fluids experiments in the challenging conditions of a microgravity environment on-board a space shuttle orbiter has been applied to obtain `cataractograms' in transgenic mice to study early onset of cataractogenesis. Cataractograms are topographical contour maps of the lens which are obtained non-invasively by scanning the eye with the probe in three-dimensions (x, y, and z directions). This new method provides a visual means, in false color, for quantitative detection and monitoring of cataracts in the entire lens. The portion of lens mapped is only limited by the degree of pupil dilation. The dilated pupil is about 1 mm for the transgenic mice system reported in this study.

Paper Details

Date Published: 22 December 1997
PDF: 9 pages
Proc. SPIE 3192, Medical Applications of Lasers in Dermatology, Ophthalmology, Dentistry, and Endoscopy, (22 December 1997); doi: 10.1117/12.297843
Show Author Affiliations
Rafat R. Ansari, NASA Lewis Research Ctr. (United States)
Kwang I. Suh, NASA Lewis Research Ctr. (United States)
Sparta J. Tumminia, National Institutes of Health (United States)
Paul Russell, National Institutes of Health (United States)
J. Samuel Zigler, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 3192:
Medical Applications of Lasers in Dermatology, Ophthalmology, Dentistry, and Endoscopy
Gregory B. Altshuler; Reginald Birngruber; Marco Dal Fante; Raimund Hibst; Herbert Hoenigsmann; Neville Krasner; Frederic Laffitte, Editor(s)

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