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Proceedings Paper

Pharmacokinetics evaluation of 132-hydroxy-bacteriopheophorbid-a methyl ester and octa-alpha-butyloxy-zinc phthalocyanine for future application in PDT
Author(s): M. Samy Ismail; Cathrin Dressler; Beate Roeder; H. Weitzel; Hans-Peter Berlien
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Paper Abstract

The pharmacokinetics of 132-hydroxy-bacteriopheophorbid-a methyl ester (132-OH-BPME) and octa-(alpha) -butyloxy-zinc phthalocyanine (8-(alpha) -bo-Zn-Pc) were studied in mice bearing Lewis lung carcinoma. Absorption spectroscopy was used to measure the photosensitizers concentrations. High 132- OH-BPME and 8-(alpha) -bo-Zn-Pc uptakes were recorded in the parenchymatous organs (liver, lung), with 8-(alpha) -bo-Zn-Pc long retention. The malignant tissues accumulated 132-OH- BPME of more than 20 folds than 8-(alpha) -bo-Zn-Pc at all incubation times. 8-(alpha) -bo-Zn-Pc concentrations in the skin and the muscle were lower than 132-OH-BPME concentrations at any interval period, but also, the 8- (alpha) -bo-Zn-Pc retained longer until 168 h. PDT with 132-OH-BPME will be more effective than with 8-(alpha) -bo- Zn-Pc where it has more concentrations in the malignant tissues.

Paper Details

Date Published: 29 December 1997
PDF: 4 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297821
Show Author Affiliations
M. Samy Ismail, Neukoelln Hospital and Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Cathrin Dressler, Laser- und Medizin-Technologie gGmbH (Germany)
Beate Roeder, Humboldt Univ. zu Berlin (Germany)
H. Weitzel, Universitaetsklinikum Benjamin Franklin der Freien Univ. Berlin (Germany)
Hans-Peter Berlien, Neukoelln Hospital and Laser- und Medizin-Technologie gGmbH (Germany)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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