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Proceedings Paper

Effect of chlorin e6 and photosensitizer-superoxide dismutase complexes on ion-transporting processes of blood cells
Author(s): Grigor Gyulkhandanyan; Anatoly P. Losev; Armen V. Gyulkhandanyan; Vladimir A. Hovhannisyan; Hakop K. Karagulyan; Margarita M, Korkhmazyan
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Paper Abstract

The interaction of aromatic amino acids, superoxide dismutase (SOD) and bovine serum albumin (BSA) with chlorin e6 (Chl) and formation of complexes were studied. The decrease of the efficiency of photochemical destruction in the absence of oxygen was observed. The changes of SOD absorption spectra in UV region agree with our former results on irreversible decrease of protein's tryptophan (Trp) luminescence under irradiation. At the same time no changes in enzymatic activity of irradiated SOD in the presence of Chl were detected. The irradiation effect on K+ and H+ ions movement across the membrane of erythrocytes loaded with Chl was studied.

Paper Details

Date Published: 29 December 1997
PDF: 6 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297820
Show Author Affiliations
Grigor Gyulkhandanyan, Institute of Biotechnology (Armenia)
Anatoly P. Losev, Institute of Molecular and Atomic Physics (Belarus)
Armen V. Gyulkhandanyan, Institute of Biochemistry (Armenia)
Vladimir A. Hovhannisyan, Laserayin tekhnika Research Institute (Armenia)
Hakop K. Karagulyan, Pharmagene Co. Ltd. (Armenia)
Margarita M, Korkhmazyan, Pharmagene Co. Ltd. (Armenia)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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