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Proceedings Paper

Photo-oxidative stability of various tetra-azaporphyrin derivatives in solution and correlation with semiempirical MO calculations
Author(s): Guenter Schnurpfeil; Abdol Khezer Sobbi; Ulrike Michelsen; Dieter Woehrle
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Paper Abstract

For the application of photosensitizers in PDT attention must be given to the stability of these compounds. For various substituted and annelated tetraazaporphyrins zinc complexes the experimentally determined first order rate constant of the photo-oxidative decomposition in DMF were compared with the calculated values of the HOMO energy level. The method described allows one to predict the photo-oxidative stability by calculating their HOMO levels which is important for the use of macrocyclic metal complexes in the photodynamic therapy of cancer. To high photo-oxidative stability leads to risks in healthy tissues and reduces photodynamic effects in tumor tissues. To low photo-oxidative stability cause problems in preparation, purification and in vivo persistency of photosensitizers for tumor treatment.

Paper Details

Date Published: 29 December 1997
PDF: 10 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297818
Show Author Affiliations
Guenter Schnurpfeil, Univ. of Bremen (Germany)
Abdol Khezer Sobbi, Univ. of Bremen (Germany)
Ulrike Michelsen, Univ. of Bremen (Germany)
Dieter Woehrle, Univ. of Bremen (Germany)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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