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Proceedings Paper

Influence of drug and light dose in determining PDT efficacy in human pancreatic cancer cells treated with zinc tetrasulfonated phthalocyanines (ZnTSPc)
Author(s): Konstantinos N. Halkiotis; Nikolaos K. Uzunoglou; Spyros Loukas; Gabriel E. Pantelias; D. Trafalis; Dido M. Yova
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Paper Abstract

Photodynamic therapy (PDT) has the potential to be applied as an adjuvant treatment modality in advanced cancer cases and recently its role in the management of pancreatic cancer, has been evaluated. Nevertheless PDT remains an experimental therapy and one of the main reasons is its complexity, as far as it relies on the combined action of the photosensitizing drug and light source. In this study was evaluated the effect of various photosensitizer and photoirradiation doses, in the lethality of MIA PaCa cell line by using ZnPcS4 as photosensitizer and a novel diode laser system as illumination source. No lethality was observed when only laser light or only photosensitizer was applied to cells. Cells treated with various concentrations of ZnTSPc and a light dose of 9 J/cm2 indicated more than 70% lethality, 24 hrs after irradiation and with a light dose of 6 J/cm2 presented almost 90% lethality, 72 hours after irradiation. The results show that low light and photosensitizer (drug) doses are enough to obtain lethality of more than 90% of MIA PaCa cells.

Paper Details

Date Published: 29 December 1997
PDF: 10 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297811
Show Author Affiliations
Konstantinos N. Halkiotis, National Technical Univ. of Athens and Institute of Biology/NCSR Demokritos (Greece)
Nikolaos K. Uzunoglou, National Technical Univ. of Athens (Greece)
Spyros Loukas, Institute of Biology/NCSR Demokritos (Greece)
Gabriel E. Pantelias, Institute of Nuclear Technology and Radiation Protection/NCSR Demokritos (Greece)
D. Trafalis, Institute of Nuclear Technology and Radiation Protection/NCSR Demokritos (Greece)
Dido M. Yova, National Technical Univ. of Athens (Greece)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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