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Proceedings Paper

Photodynamic therapy of head and neck cancer with different sensitizers
Author(s): Elena G. Vakoulovskaya; Victor V. Shental; N. A. Abdoullin; Yury P. Kuvshinov; T. D. Tabolinovskaia; N. J. Edinak; Boris K. Poddubny; T. T. Kondratjeva; Gennadii A. Meerovich; Alexander A. Stratonnikov; Kirill G. Linkov; Valery V. Agafonov
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Paper Abstract

This paper deals with the results of clinical trials for sulfated aluminum phthalocyanine (PHS) (Photosens, Russia) and Photogeme (PG) in Russia. The results of photodynamic therapy (PDT) of head and neck tumors (HNT), side effects and ways of their correction and prevention, as well as possibility to work out less toxic regimes of PDT with photosense, choice of laser and type of irradiation are discussed. PDT have been provided in 79 patients with different head and neck tumors. Efficacy of PDT depended on tumor size and its histological type. Undesirable changes in plasma content of antioxidants by means of high pressure liquid chromatography (HLPC) have been found in patients after PHS injection. Influence of short-term and long-term supplementation with beta-carotene and vitamin E on this parameters are discussed.

Paper Details

Date Published: 29 December 1997
PDF: 5 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297809
Show Author Affiliations
Elena G. Vakoulovskaya, Cancer Research Ctr. (Russia)
Victor V. Shental, Cancer Research Ctr. (Russia)
N. A. Abdoullin, Cancer Research Ctr. (Russia)
Yury P. Kuvshinov, Cancer Research Ctr. (Russia)
T. D. Tabolinovskaia, Cancer Research Ctr. (Russia)
N. J. Edinak, Cancer Research Ctr. (Russia)
Boris K. Poddubny, Cancer Research Ctr. (Russia)
T. T. Kondratjeva, Cancer Research Ctr. (Russia)
Gennadii A. Meerovich, General Physics Institute (Russia)
Alexander A. Stratonnikov, General Physics Institute (Russia)
Kirill G. Linkov, General Physics Institute (Russia)
Valery V. Agafonov, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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