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Proceedings Paper

Systemic estimation of the effect of photodynamic therapy of cancer
Author(s): Eugenia A. Kogan; Gennadii A. Meerovich; Nadezgda L. Torshina; Victor B. Loschenov; Anna I. Volkova; Anna M. Posypanova
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Paper Abstract

The effects of photodynamic therapy (PDT) of cancer needs objective estimation and its unification in experimental as well as in clinical studies. They must include not only macroscopical changes but also the complex of following morphological criteria: (1) the level of direct tumor damage (direct necrosis and apoptosis); (2) the level of indirect tumor damage (ischemic necrosis); (3) the signs of vascular alterations; (4) the local and systemic antiblastome resistance; (5) the proliferative activity and malignant potential of survival tumor tissue. We have performed different regimes PDT using phthalocyanine derivatives. The complex of morphological methods (Ki-67, p53, c-myc, bcl-2) was used. Obtained results showed the connection of the tilted morphological criteria with tumor regression.

Paper Details

Date Published: 29 December 1997
PDF: 6 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297803
Show Author Affiliations
Eugenia A. Kogan, Moscow Medical Academy (Russia)
Gennadii A. Meerovich, General Physics Institute (Russia)
Nadezgda L. Torshina, General Physics Institute (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)
Anna M. Posypanova, General Physics Institute (Russia)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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