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Proceedings Paper

In-vivo photodynamic activity of mTHPC poly(ethylene glycol) conjugates (SC102)
Author(s): Michael F. Grahn; Anita McGuinness; Martin L. de Jode; Andreas Giger; Amarpreet S. Dhiman; Chi-Ming Cheung; Sharon Pavitt; Robin Benzie; Norman S. Williams
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Paper Abstract

The photosensitizer m-THPC (temoporfin, FoscanR) is probably the most potent compound currently being tested for clinical use in photodynamic therapy. However, this compound is not freely water soluble and is extensively taken up and excreted by the liver following injection. This paper describes the initial characterization of a group of water- soluble poly(ethylene glycol) conjugates of m-THPC (SC102) in a mouse model system. The use of a carbonate linking group results in a labile compound which produced very high systemic photosensitivity at early times after injection. Triazine linked conjugates were stable both in vitro and in vivo and, although less potent than m-THPC on a molar basis, were capable of producing equivalent tumor necrosis accompanied by relatively low levels of muscle damage. In addition, SC102 tumor necrosis was seen over a wide range of drug-light intervals suggesting that these compounds may be less sensitive to treatment conditions than is m-THPC.

Paper Details

Date Published: 29 December 1997
PDF: 7 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297801
Show Author Affiliations
Michael F. Grahn, St. Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
Anita McGuinness, St. Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
Martin L. de Jode, St. Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
Andreas Giger, Univ. of Bern (Switzerland)
Amarpreet S. Dhiman, Kingston Univ. (United Kingdom)
Chi-Ming Cheung, Kingston Univ. (United Kingdom)
Sharon Pavitt, Kingston Univ. (United Kingdom)
Robin Benzie, St. Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)
Norman S. Williams, St. Bartholomew's and Royal London School of Medicine and Dentistry (United Kingdom)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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