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Proceedings Paper

Improvement of cancer PDT using sulphophthalocyanine and sodium ascorbate
Author(s): Oleg L. Kalija; Gennadii A. Meerovich; Nadezgda L. Torshina; Eugenia A. Kogan; Victor B. Loschenov; Eugeny A. Lukyanets; Boris Ya. Kogan; Alexander V. Butenin; Georgy N. Vorozhtsov; Sergei G. Kuzmin; Anna I. Volkova; Anna M. Posypanova
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Paper Abstract

It is well known that sulphophthalocyanines induce in process of PDT photochemical reaction of II type with generation of cytotoxic agent -- singlet oxygen. The combination of phthalocyanine and exogenic reductant -- sodium ascorbate may also induce other reactions, involving the formation of free radicals, and thus intensify the antitumor effect. The mechanism of action of the ascorbate may be connected also with the direct tumor cells damage (apoptosis) and with the stimulation of antiblastome resistance. We conducted the experimental study on 150 white mice with Erlich carcinoma. Macroscopic and microscopic data showed that ascorbate significantly increases the effect of PDT in comparison with control group due to the higher tumor damage, inhibition of its growth and stimulation of antitumor desmoplastic reaction.

Paper Details

Date Published: 29 December 1997
PDF: 3 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297800
Show Author Affiliations
Oleg L. Kalija, Organic Intermediates and Dyes Institute (Russia)
Gennadii A. Meerovich, General Physics Institute (Russia)
Nadezgda L. Torshina, General Physics Institute (Russia)
Eugenia A. Kogan, Moscow Medical Academy (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Eugeny A. Lukyanets, Organic Intermediates and Dyes Institute (Russia)
Boris Ya. Kogan, Organic Intermediates and Dyes Institute (Russia)
Alexander V. Butenin, Organic Intermediates and Dyes Institute (Russia)
Georgy N. Vorozhtsov, Organic Intermediates and Dyes Institute (Russia)
Sergei G. Kuzmin, Organic Intermediates and Dyes Institute (Russia)
Anna I. Volkova, General Physics Institute (Russia)
Anna M. Posypanova, General Physics Institute (Russia)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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