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Proceedings Paper

Infusion technique allowing long-term tumor targeting with antibodies on the hen's egg test (HET) system
Author(s): Anja Vervoorts; Tatyana A. Karmakova; Irene Rose; Joerg G. Moser
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Paper Abstract

The accumulation of antibodies or their fragments in tumor tissues is a basal requirement for immunotargeting of tumors in vivo. Immunotargeting is the first step for a polyphasic tumor therapy and diagnosis. Usually the high interstitial pressure and the insufficient blood supply of the tumor prevents the accumulation of tumor specific antibodies. To overcome these barriers the antibodies can be modified concerning their molecular weight. On the other hand, different injection techniques can influence the antibody distribution in-vivo. We developed a long term infusion technique for the testing of antibodies and antibody fragments in xenotransplanted tumors in the hen's egg test system. This in-vivo model allows to develop new protocols for the antibody administration resulting in a tumor localization without targeting of non-tumor tissues. Macroscopic and microscopic findings in the HET-system may reflect the binding sites of antibodies in-situ. Detection of tumor markers has not yet been realized due to problems inherent to the system.

Paper Details

Date Published: 29 December 1997
PDF: 9 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297799
Show Author Affiliations
Anja Vervoorts, Institute of Laser Medicine/Univ. of Duesseldorf (Germany)
Tatyana A. Karmakova, P.A. Hertzen Institute of Oncology Research (Russia)
Irene Rose, Institute of Laser Medicine/Univ. of Duesseldorf (Germany)
Joerg G. Moser, Institute of Laser Medicine/Univ. of Duesseldorf (Germany)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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