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Proceedings Paper

Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids cancer cells using sulphonated phthalocyanine aluminum photosensitizer
Author(s): Alexandre Yu. Douplik; Victor B. Loschenov; Georgy N. Vorozhtsov; Eugenia A. Kogan; Michael Kusin; Y. Ablitsov; O. S. Ilyina
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Paper Abstract

Discovered during last year's phenomenon of PDT-induced apoptosis (programmed cell destruction) in cell culture immediately after light irradiation using phthalocyanine photosensitizers can be used for treatment of cancer. Experiments were carried out on mice with ascites. Ascitic liquid with the added photosensitizer was irradiated by light source with wavelength 660 - 680 nm and used according to ex vivo procedure. Actuation and development of apoptosis process in ascitic liquid were estimated by cytomorphological tests. It has been observed the phenomenon of growth of relative fraction of cells damage level expressed mainly as apoptosis after PDT procedure ex vivo. We suggest to call this phenomenon as PDT-induced post-irradiation apoptosis (PIP- apoptosis). Dependence between level of expressing of PIP- apoptosis and sulphonated phthalocyanine aluminum photosensitizer (Photosense) concentration at used photosensitizer concentrations has not been found out.

Paper Details

Date Published: 29 December 1997
PDF: 6 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297793
Show Author Affiliations
Alexandre Yu. Douplik, General Physics Institute (Russia)
Victor B. Loschenov, General Physics Institute (Russia)
Georgy N. Vorozhtsov, Organic Intermediates and Dyes Institute (Russia)
Eugenia A. Kogan, Moscow Medical Academy (Russia)
Michael Kusin, Moscow Medical Academy (Russia)
Y. Ablitsov, Moscow Medical Academy (Russia)
O. S. Ilyina, Moscow Medical Academy (Russia)

Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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