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Proceedings Paper

Dynamics of photosensitizers in cell cultures and nonanimal in-vivo systems
Author(s): Angelika C. Rueck; Nermin Akguen; K. Heckelsmiller; Gerd C. Beck; Karin Kunzi-Rapp
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Paper Abstract

The biochemical background of photodynamic therapy is only partly resolved. The biodynamic, which is shown to be different for lipophilic and hydrophilic photosensitizers influences the photodynamic efficiency. A complex cellular and subcellular localization and relocalization of the drugs is not only observed with varying incubation time but also during the light induced process. The dynamic behavior of lipophilic and hydrophilic phthalocyanines in cell cultures and non animal in vivo systems will be summarized within the presentation. As in vivo system the chorioallantoic membrane (CAM) of fertilized eggs was used. The dynamic behavior was observed with a confocal laser scanning microscope.

Paper Details

Date Published: 29 December 1997
PDF: 5 pages
Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); doi: 10.1117/12.297787
Show Author Affiliations
Angelika C. Rueck, Institut fuer Lasermedizin in der Medizin und Messtechnik an der Univ. Ulm (Germany)
Nermin Akguen, Institut fuer Lasermedizin in der Medizin und Messtechnik an der Univ. Ulm (Germany)
K. Heckelsmiller, Institut fuer Lasermedizin in der Medizin und Messtechnik an der Univ. Ulm (Germany)
Gerd C. Beck, Institut fuer Lasermedizin in der Medizin und Messtechnik an der Univ. Ulm (Germany)
Karin Kunzi-Rapp, Institut fuer Lasermedizin in der Medizin und Messtechnik an der Univ. Ulm (Germany)


Published in SPIE Proceedings Vol. 3191:
Photochemotherapy: Photodynamic Therapy and Other Modalities III
Kristian Berg; Benjamin Ehrenberg; Zvi Malik; Johan Moan; Abraham Katzir, Editor(s)

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