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Proceedings Paper

Building artificial networks of neuronal cells with light-assisted polymer surface functionalization
Author(s): Dan V. Nicolau; Hideo Taniguchi; Takahisa Taguchi; Susumu Yoshikawa
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Paper Abstract

The surface of photosensible diazo-naphto-quinone/novolak film was chemically manipulated through UV exposure and subsequent functionalization processes to obtain surfaces with different chemistries (DNQ, carboxylic, and peptidic groups). The neuronal cell attachment is controlled by three pairs of antagonistic surface variables: charged/uncharged species, amino/carboxylic groups and hydrophilic/hydrophobic balance, in which the former promote the adhesion. The study proves that microlithographic techniques in connection with surface functionalization with specific neuro-peptides can be used to build artificial networks with neuronal cells.

Paper Details

Date Published: 14 November 1997
PDF: 7 pages
Proc. SPIE 3241, Smart Materials, Structures, and Integrated Systems, (14 November 1997); doi: 10.1117/12.293501
Show Author Affiliations
Dan V. Nicolau, Osaka National Research Institute (Japan)
Hideo Taniguchi, Osaka National Research Institute (Japan)
Takahisa Taguchi, Osaka National Research Institute (Japan)
Susumu Yoshikawa, Osaka National Research Institute (Japan)

Published in SPIE Proceedings Vol. 3241:
Smart Materials, Structures, and Integrated Systems
Alex Hariz; Vijay K. Varadan; Olaf Reinhold, Editor(s)

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