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Proceedings Paper

Building artificial networks of protein molecular motors
Author(s): Dan V. Nicolau; Hitoshi Suzuki; Hideo Taniguchi; Takahisa Taguchi; Susumu Yoshikawa; Shinro Mashiko
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Paper Abstract

This study attempts to assess the feasibility of building purposefully designed molecular motor arrays, the proteins responsible for the movements of the living organisms and cells. The 'building' process used high-resolution e-beam patterning, originating in semiconductor technology, upgraded to make biomicrolithography compatible with the patterning of bioactive molecules. The material used as a scaffold for the array [a copolymer of poly(tert-butyl-methacrylate/methyl- methacrylate)] was tailored to exhibit large difference in hydrophobicity when exposed to e-beam exposure. The e-beam patterning exposure-induced difference in hydrophobicity is responsible for the selective attachment of the myosin molecules on the patterned deep-submicron 'tracks,' and the higher concentration of 'guiding' molecules selectively confines the movement of the actin filaments.

Paper Details

Date Published: 14 November 1997
PDF: 11 pages
Proc. SPIE 3241, Smart Materials, Structures, and Integrated Systems, (14 November 1997); doi: 10.1117/12.293481
Show Author Affiliations
Dan V. Nicolau, Osaka National Research Institute (Japan)
Hitoshi Suzuki, Communications Research Labs. (Japan)
Hideo Taniguchi, Osaka National Research Institute (Japan)
Takahisa Taguchi, Osaka National Research Institute (Japan)
Susumu Yoshikawa, Osaka National Research Institute (Japan)
Shinro Mashiko, Communications Research Labs. (Japan)


Published in SPIE Proceedings Vol. 3241:
Smart Materials, Structures, and Integrated Systems
Alex Hariz; Vijay K. Varadan; Olaf Reinhold, Editor(s)

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