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Proceedings Paper

Synchrotron infrared microspectroscopy as a means of studying the chemical composition of bone: applications to osteoarthritis
Author(s): Lisa M. Miller; Cathy S. Carlson; G. Lawrence Carr; Gwyn P. Williams; Mark R. Chance
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Paper Abstract

Infrared microspectroscopy combines microscopy and spectroscopy for the purpose of chemical microanalysis. Light microscopy provides a way to generate and record magnified images and visibly resolve microstructural detail. Infrared spectroscopy provides a means for analyzing the chemical makeup of materials. Combining light microscopy and infrared spectroscopy permits the correlation of microstructure with chemical composition. Inherently, the long wavelengths of infrared radiation limit the spatial resolution of the technique. However, synchrotron infrared radiation significantly improves both the spectral and spatial resolution of an infrared microspectrometer, such that data can be obtained with high signal-to-noise at the diffraction limit, which is 3 - 5 micrometers in the mid-infrared region.

Paper Details

Date Published: 16 October 1997
PDF: 8 pages
Proc. SPIE 3153, Accelerator-Based Infrared Sources and Applications, (16 October 1997); doi: 10.1117/12.290258
Show Author Affiliations
Lisa M. Miller, Albert Einstein College of Medicine and Brookhaven National Lab. (United States)
Cathy S. Carlson, Bowman Gray School of Medicine/Wake Forest Univ. (United States)
G. Lawrence Carr, Brookhaven National Lab. (United States)
Gwyn P. Williams, Brookhaven National Lab. (United States)
Mark R. Chance, Albert Einstein College of Medicine and Brookhaven National Lab. (United States)

Published in SPIE Proceedings Vol. 3153:
Accelerator-Based Infrared Sources and Applications
Gwyn P. Williams; Paul Dumas, Editor(s)

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