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Proceedings Paper

Laser optoacoustic tomography of layered tissues: signal processing
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Paper Abstract

Laser optoacoustic imaging experiments in biological tissues in vivo are presented along with the theoretical signal analysis procedure. The laser optoacoustic imaging system (LOIS) can operate in the reflection mode with emphasis on high z-axial (in-depth) resolution (up to 10 - 20 micrometers). Two examples of LOIS applications for non- invasive in vivo medical diagnostics are presented and discussed: (1) characterization of layered structure of port- wine stains, and (2) measurements of skin melanoma thickness. Potential miniaturization of LOIS for endoscopy applications is also discussed. The z-axial profiles of laser-induced pressure were shown to contain diagnostic information on location, dimensions and optical properties of tissue layers. Time-resolved signals detected by piezoelectric transducers were corrected for distortions such as diffraction and acoustic attenuation that occur upon pressure wave propagation in tissue. Wavelet transform applied to signals of laser- induced acoustic emission yielded high contrast pressure profiles with substantial signal-to-noise ratio.

Paper Details

Date Published: 18 August 1997
PDF: 12 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280297
Show Author Affiliations
Alexander A. Oraevsky, Rice Univ. (United States)
Rinat O. Esenaliev, Rice Univ. (United States)
Alexander A. Karabutov, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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