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Proceedings Paper

Influence of tissue inhomogeneities on estimates of tissue optical properties obtained from steady-state reflectometry
Author(s): Thomas J. Farrell; Michael S. Patterson; Matthias Essenpreis; Michael Hein; Dirk Boecker
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Paper Abstract

Most instrumentation used to measure tissue optical properties non-invasively employ data analysis algorithms which rely upon the simplifying assumption that the tissue is semi-infinite and homogeneous. The influence of a layered tissue architecture on the determination of the scattering and absorption coefficients has been investigated. Steady state reflectance data for a two-layered tissue architecture were generated using a Monte Carlo code. These were analyzed using a diffusion theory model to calculate the scatter and absorption coefficients. The estimated tissue optical properties were different from those for either layer, and for certain choices of input optical properties would result in physically impossible results. The sensitivity and specificity of the estimated optical properties to changes in input optical properties were calculated for different layered geometries. For typical optical properties of skin the results suggest that a change in the absorption coefficient of 100% will result in an apparent change in scatter coefficient of 15% and that a similar change only in scatter coefficient will result in an apparent change of 100% in absorption coefficient.

Paper Details

Date Published: 18 August 1997
PDF: 8 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280262
Show Author Affiliations
Thomas J. Farrell, Hamilton Regional Cancer Ctr. and McMaster Univ. (Canada)
Michael S. Patterson, Hamilton Regional Cancer Ctr. and McMaster Univ. (Canada)
Matthias Essenpreis, Boehringer Mannheim GmbH (Germany)
Michael Hein, Boehringer Mannheim GmbH (Germany)
Dirk Boecker, Boehringer Mannheim GmbH (Germany)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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