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Proceedings Paper

Use of time-dependent contrast functions to discriminate between the scattering and absorption properties of abnormal regions hidden within a tissue-like phantom
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Paper Abstract

The success of time-resolved imaging of an abnormal site embedded in thick tissue may rely on one's ability to quantify the absorption coefficient of the target as a specific spectroscopic signature. This task is particularly complicated when the scattering properties of the target differ from those of the surrounding tissue. Using data obtained from time- resolved transillumination experiments of abnormally absorbing and differentially scattering objects embedded in a tissue- like phantom, we show how a new deconvolution algorithm enables us to quantify the optical properties of the target. The algorithm is based on a photon random walk theory that expresses different time-dependent point spread functions to calculate the diffusive and absorptive contrasts obtained in time-of-flight measurements.

Paper Details

Date Published: 18 August 1997
PDF: 7 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280246
Show Author Affiliations
Amir H. Gandjbakhche, National Institutes of Health (Israel)
Victor V. Chernomordik, National Institutes of Health (Israel)
Robert F. Bonner, National Institutes of Health (United States)
Jeremy C. Hebden, Univ. College London (United Kingdom)
Ralph J. Nossal, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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