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Proceedings Paper

Enhanced optical scattering by microbubbles
Author(s): Quing Zhu; Britton Chance; W. Timothy Jenkins; Yutao Zhang
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Paper Abstract

Optical properties of microbubbles (EchoGen, Sonus Pharmaceuticals, WA) have been evaluated using a 200 MHz phase modulation system. Studies have shown that the mean optical pathlength has been increased at 754 nm by an average of 1.5 mm (std. 0.46 mm) when EchoGen was administered to 11 Fischer rats at the dose of 100 (mu) l or 150 (mu) l. As a comparison, the mean pathlength has been decreased at the same wavelength by an average of 4.2 mm (std. 3.66 mm) when indocyanine green (ICG) was administered at the dose of 100 (mu) l. The mean pathlength change at 816 nm is very small and the possible reasons are discussed. Potential applications of using microbubbles to provide a co-registration of ultrasound and light images of growing tumors are discussed.

Paper Details

Date Published: 18 August 1997
PDF: 6 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280242
Show Author Affiliations
Quing Zhu, Hospital of the Univ. of Pennsylvania (United States)
Britton Chance, Hospital of the Univ. of Pennsylvania (United States)
W. Timothy Jenkins, Hospital of the Univ. of Pennsylvania (United States)
Yutao Zhang, Hospital of the Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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