Share Email Print
cover

Proceedings Paper

Quantitative detection of multiple fluorophore sites as a tool for diagnosis and monitoring disease progression in salivary glands
Author(s): Israel Gannot; Robert F. Bonner; Gallya Gannot; Philip C. Fox; Joon Shik You; Ronald W. Waynant; Amir H. Gandjbakhche
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

A series of fluorescent surface images were obtained from physical models of localized fluorophores embedded at various depths and separations in tissue phantoms. Our random walk theory was applied to create an analytical model of multiple flurophores embedded in tissue-like phantom. Using this model, from acquired set of surface images, the location of the fluorophores was reconstructed and compared it to their known 3-D distributions. A good correlation was found, and the ability to resolve fluorophores as a function of depth and separation was determined. In parallel in in-vitro study, specific coloring of sections of minor salivary glands was also demonstrated. These results demonstrate the possibility of using inverse methods to reconstruct unknown locations and concentrations of optical probes specifically bound to infiltrating lymphocytes in minor salivary glands of patients with Sjogren's syndrome.

Paper Details

Date Published: 18 August 1997
PDF: 6 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280241
Show Author Affiliations
Israel Gannot, FDA Ctr. for Devices and Radiological Health (United States)
Robert F. Bonner, National Institutes of Health (United States)
Gallya Gannot, National Institutes of Health (United States)
Philip C. Fox, National Institutes of Health (United States)
Joon Shik You, National Institutes of Health (United States)
Ronald W. Waynant, FDA Ctr. for Devices and Radiological Health (United States)
Amir H. Gandjbakhche, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

© SPIE. Terms of Use
Back to Top