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Proceedings Paper

Photon migration imaging using multipixel measurements
Author(s): Tamara L. Troy; Jeffery S. Reynolds; Eva Marie Sevick-Muraca
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Paper Abstract

In order to reconstruct images of heterogeneities embedded deep within tissues, multiple-pixel measurements of frequency domain photon migration are necessary. Typically, these measurements are performed at multiple locations on the periphery of the sample using individual fiber optics. However, measurements using multiple fiber optics are both tedious and time consuming, especially as one increases spatial measurement resolution. In our research, we acquire multi-pixel measurements by employing a gain-modulated image intensified CCD camera and near infrared milliwatt laser diodes to monitor the propagation characteristics of sinusoidally modulated light as it passes through tissue-like phantoms containing 0.5% intralipid solutions. Our results show that images of millimeter sized absorbing objects located greater than 1 cm inside an ideal tissue phantom an be successfully obtained. In addition, we have been able to generate fluorescent images locating portions of micromolar concentrations of indocyanine green embedded within an intralipid solution contained within a glass cylindrical vessel (10 mm by 4 mm diameter).

Paper Details

Date Published: 18 August 1997
PDF: 11 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280237
Show Author Affiliations
Tamara L. Troy, Purdue Univ. (United States)
Jeffery S. Reynolds, Purdue Univ. (United States)
Eva Marie Sevick-Muraca, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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