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Concentration, size, mean lifetime, and noise effects on image quality in luminescence optical tomography
Author(s): Jenghwa Chang; Harry L. Graber; Randall Locke Barbour
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Paper Abstract

The impact of background lumiphore in luminescence optical tomography is examined. To demonstrate its effects, numerical simulations were performed to calculate the diffusion-regime limiting form of forward-problem solutions for a specific test medium. Image reconstructions were performed using a CGD algorithm with a rescaling technique and positivity constraints. In addition, we develop a modification to the basic algorithm that makes use of the maximum possible concentration in order to estimate the background concentration, and show that it improves image quality when background lumiphore is present. We conclude that the usual measure of background lumiphore's effect, which is the target- to-background lumiphore concentration ratio, is not adequate to define the contribution from the background lumiphore. The reason for this is that image quality is also a function of target size and location. An alternative measure that we find superior is described. The results indicate that the improved algorithm yields better image quality for low target-to- background ratios.

Paper Details

Date Published: 18 August 1997
PDF: 9 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280221
Show Author Affiliations
Jenghwa Chang, SUNY/Brooklyn (United States)
Harry L. Graber, SUNY/Brooklyn (United States)
Randall Locke Barbour, SUNY/Brooklyn (United States)

Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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