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Proceedings Paper

Oximetry with phase modulation NIR spectroscopy based on phase measurement only
Author(s): Vasilis Ntziachristos; Nikolai C. Brun; Bjorn Feet; Gorm Greisen; Britton Chance
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Paper Abstract

Near infrared spectroscopy, based on frequency domain methods, has been successfully applied to study turbid media, using amplitude and phase measurements. Oximetry based on phase measurements only may prove advantageous over amplitude phase measurements due to relative simplicity of use and calibration of systems with phase output only. Suggestions for hemoglobin saturation calculation, based on the diffusion approximation and phase information only, have been proposed in the past. There exist many factors though that may introduce inaccuracies in the data analysis and in the measurements, besides the inherent inability of such systems to account for absorption of water and chromophores besides oxy- and deoxy- hemoglobin. Such factors, as theoretical approximations, voltage to phase conversion and initial phase calibration, have to be carefully considered in order to produce consistent and reliable calculations. In the present work, simulation models, based on the solution of the diffusion equation in the frequency domain, have been developed, to study the performance of different approximations used for the calculation of hemoglobin saturation. A new approach for data analysis is presented and investigated. Methods for instrument calibration are discussed and an example, based on experimental measurements, is demonstrated.

Paper Details

Date Published: 18 August 1997
PDF: 9 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280217
Show Author Affiliations
Vasilis Ntziachristos, Univ. of Pennsylvania (United States)
Nikolai C. Brun, Rigshospitalet/Univ. of Copenhagen (Denmark)
Bjorn Feet, Rikshospitalet/Univ. of Oslo (Norway)
Gorm Greisen, Rigshospitalet/Univ. of Copenhagen (Denmark)
Britton Chance, Univ. of Pennsylvania (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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