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Proceedings Paper

Laser optoacoustic imaging for breast cancer diagnostics: limit of detection and comparison with x-ray and ultrasound imaging
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Paper Abstract

Laser optoacoustic imaging is a promising diagnostic technique for early breast cancer detection. Capability of laser optoacoustic imaging for visualization of small spherical tumor phantoms located within the bulk collagen gels was studied. The experiments were performed with breast phantoms made of optically turbid collagen gel. Optical properties of the phantom resembled the optical properties of human breast at the wavelength of irradiation, 1064 nm ((mu) a equals 0.11 1/cm, (mu) s' equals 2.92 1/cm). Gel spheres with a higher absorption coefficient, (mu) v equals 0.75 1/cm were used to simulate tumors. The experiments demonstrated the capability of laser optoacoustic imaging to detect and localize 2-mm 'tumors' at a depth of up to 60 mm within 100-mm thick breast phantoms. Laser optoacoustic images of the phantom tumors were reconstructed from experimentally measured pressure profiles. The optoacoustic images were compared with images obtained with x-ray mammography and ultrasonography. Comparative study revealed experimental conditions and phantom structure for which the laser optoacoustic imaging outperformed both the x-ray mammography and the ultrasonography. The results suggest that the laser optoacoustic imaging may occupy an important niche in breast cancer diagnostics, particularly, for diagnosis of small tumors in radiologically dense and acoustically homogeneous breast tissues.

Paper Details

Date Published: 18 August 1997
PDF: 12 pages
Proc. SPIE 2979, Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II, (18 August 1997); doi: 10.1117/12.280213
Show Author Affiliations
Rinat O. Esenaliev, Rice Univ. (United States)
Alexander A. Karabutov, Rice Univ. (United States)
Frank K. Tittel, Rice Univ. (United States)
Bruno D. Fornage, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Sharon L. Thomsen, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Carol Stelling, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Alexander A. Oraevsky, Rice Univ. (United States)


Published in SPIE Proceedings Vol. 2979:
Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model, and Human Studies II
Britton Chance; Robert R. Alfano, Editor(s)

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