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Proceedings Paper

CsI(Na)-based radiation detector for high-resolution imaging studies using iodine 125 in small-animal research
Author(s): Andrew G. Weisenberger; Eric Bradley; Stan Majewski; Margaret Saha
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Paper Abstract

We report on the development of a high resolution radiation imaging system which is capable of detecting and imaging the coincident gamma and x-ray emissions of the radioisotope iodine 125 (125I). Iodine 125 is commonly available as a label to molecular biology probes. Iodine 125 decays via electron capture emitting a 35 keV gamma-ray with the prompt emission of several 27 - 32 keV x rays. A coincidence condition can be set to detect the 125I decays thus reducing background radiation contribution to the image. We are testing the use of arrays of CsI(Na) crystal scintillators coupled to position sensitive photomultiplier tubes for this application. Laboratory studies have thus far been done on mice using a prototype of our detector which is intended to be used to image gene expression in live mice to advance research in neurobiology.

Paper Details

Date Published: 7 July 1997
PDF: 9 pages
Proc. SPIE 3115, Hard X-Ray and Gamma-Ray Detector Physics, Optics, and Applications, (7 July 1997); doi: 10.1117/12.277692
Show Author Affiliations
Andrew G. Weisenberger, Thomas Jefferson National Accelerator Facility (United States)
Eric Bradley, College of William and Mary (United States)
Stan Majewski, Thomas Jefferson National Accelerator Facility (United States)
Margaret Saha, College of William and Mary (United States)


Published in SPIE Proceedings Vol. 3115:
Hard X-Ray and Gamma-Ray Detector Physics, Optics, and Applications
Richard B. Hoover; F. Patrick Doty, Editor(s)

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