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Proceedings Paper

Monitoring of rapid blood pH variations by CO detection in breath with tunable diode laser
Author(s): Andrian I. Kouznetsov; Eugene V. Stepanov; Pavel V. Zyrianov; Yurii A. Shulagin; Alexander I. Diachenko; Youri I. Gurfinkel
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Paper Abstract

Detection of endogenous carbon monoxide content in breath with tunable diode lasers (TDL) was proposed for noninvasive monitoring of rapid blood pH variation. Applied approach is based on high sensitivity of the haemoglobin and myoglobin affinity for CO to blood pH value and an ability to detect rapidly small variations of CO content in expired air. Breath CO absorption in 4.7 micrometers spectral region was carefully measured using PbSSe tunable diode laser that can provide 1 ppb CO concentration sensitivity and 10 s time constant. Applied TDL gas analyzer was used to monitor expired air of studied persons in physiological tests including hyperventilation and physical load. Simultaneous blood tests were conducted to demonstrate correlation between blood and breath chemical parameters.

Paper Details

Date Published: 16 June 1997
PDF: 8 pages
Proc. SPIE 2976, Biomedical Sensing, Imaging, and Tracking Technologies II, (16 June 1997); doi: 10.1117/12.275517
Show Author Affiliations
Andrian I. Kouznetsov, General Physics Institute (Russia)
Eugene V. Stepanov, General Physics Institute (Russia)
Pavel V. Zyrianov, General Physics Institute (Russia)
Yurii A. Shulagin, Institute of Biomedical Problems (Russia)
Alexander I. Diachenko, Institute of Biomedical Problems (Russia)
Youri I. Gurfinkel, Center of Biomagnetism (Russia)


Published in SPIE Proceedings Vol. 2976:
Biomedical Sensing, Imaging, and Tracking Technologies II
Tuan Vo-Dinh; Robert A. Lieberman; Gerald G. Vurek; Abraham Katzir, Editor(s)

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