Share Email Print
cover

Proceedings Paper

In-vivo plasma-mediated ablation as a function of laser pulse width
Author(s): Xinbing Liu; An-Chun Tien; Tibor Juhasz; Barbara Irish; Victor Elner; Ron M. Kurtz
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

We evaluated in vivo wound healing responses to plasma- mediated ablation in skin as a function of laser pulsewidth and energy. Experiments utilized a regeneratively amplified Ti:Sapphire laser operating at 800 nm with pulsewidths varied from 7 ns to 100 fs. Skin incisions were created in mice by tightly focusing the laser beam on the tissue surface. Incisions of equal depth were compared at time points ranging from 6 hours to 3 weeks using standard histologic methods. Incision depth was proportional to pulse energy at each pulsewidth. Fluence threshold dependence on laser pulsewidth agreed with those predicted by ex vivo testing. Histologic analysis revealed minimal adjacent tissue damage at pulsewidths less than a few picoseconds and energies near the fluence threshold. Longer pulsewidths and higher fluence levels were associated with more significant collateral effects. These in vivo results suggest collateral tissue damage and secondary effects may be minimized by controlling laser pulsewidth and energy.

Paper Details

Date Published: 16 June 1997
PDF: 7 pages
Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); doi: 10.1117/12.275509
Show Author Affiliations
Xinbing Liu, Ctr. for Ultrafast Optical Science/Univ. of Michigan (United States)
An-Chun Tien, Ctr. for Ultrafast Optical Science/Univ. of Michigan (United States)
Tibor Juhasz, Kellogg Eye Ctr./Univ. of Michigan (United States)
Barbara Irish, Kellogg Eye Ctr./Univ. of Michigan (United States)
Victor Elner, Kellogg Eye Ctr./Univ. of Michigan (United States)
Ron M. Kurtz, Kellogg Eye Ctr./Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 2975:
Laser-Tissue Interaction VIII
Steven L. Jacques, Editor(s)

© SPIE. Terms of Use
Back to Top