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Proceedings Paper

Optical real-time measurement of collagen denaturation
Author(s): Vanitha Sankaran M.D.; Joseph T. Walsh Jr.
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Paper Abstract

Linear birefringence is a property of collagenous tissue that results from both its composition and structure. Previous investigations have shown that birefringence provides an indication of structural changes in collagen during slow heating. We now report the birefringent response of both mature and young rat tail tendon to laser-heating. The results indicate that denaturation of collagen from mature rats induced by a 200-microsecond(s) -long Ho:YAG laser pulse may not be described accurately by kinetic parameters. Several second-long pulses of CO2 laser pulse may not be described from young rats fit an Arrhenius model with Ea equals 12.1 kcal/mol and A equals e18.03 s-1. Typically, for slow-heating of collagen, Ea equals kcal/mol and A equals e120 s-1. Thus, it seems likely that the temperature and energy needed to initiate collagen denaturation is lower in young collagen, possibly due to its decreased hydroxyproline content and consequent decreased thermal stability.

Paper Details

Date Published: 16 June 1997
PDF: 9 pages
Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); doi: 10.1117/12.275490
Show Author Affiliations
Vanitha Sankaran M.D., Northwestern Univ. (United States)
Joseph T. Walsh Jr., Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 2975:
Laser-Tissue Interaction VIII
Steven L. Jacques, Editor(s)

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