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Proceedings Paper

Morphologic evaluations of Q-switched Nd:YAG laser injury of human retina
Author(s): David K. Scales; Steven T. Schuschereba; David J. Lund; Bruce E. Stuck
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Paper Abstract

Depiction of the cellular and immune responses in the human model is critical to design rational therapies preventing/limiting cellular destruction and ultimately functional visual loss following acute laser injuries. We report the light and electron microscopy histologic findings in a controlled ocular human laser exposure. Following informed consent, the normal eye of a patient scheduled to undergo exenteration for invasive carcinoma of the orbit was exposed to both continuous wave and Q-switched lasers. Four hours prior to exenteration, argon G lesions were placed in the superior/temporal quadrant and Nd:YAG lesions were placed in the inferior/temporal quadrant. After enucleation, the retina was prepared for routine light and transmission electron microscopy. Histology of the argon G lesions showed primarily photoreceptor and RPE photocoagulation damage. Neutrophil adhesion was limited within the choroid and no neutrophils were observed in the subretinal space. In contrast, the 4 hr Nd:YAG lesions showed extensive retinal disruption, hemorrhage within subretinal and intraretinal spaces, neutrophil accumulation in the retina, and an extensive neutrophil chemotaxic and emigration response in the choroid. Severe laser injuries elicit a significant neutrophil response by 4 hr, suggesting that neutrophils should be an early stage therapeutic target.

Paper Details

Date Published: 2 May 1997
PDF: 7 pages
Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); doi: 10.1117/12.275248
Show Author Affiliations
David K. Scales, Wilford Hall Medical Ctr. (United States)
Steven T. Schuschereba, Walter Reed Army Institute of Research (United States)
David J. Lund, Walter Reed Army Institute of Research (United States)
Bruce E. Stuck, Walter Reed Army Institute of Research (United States)

Published in SPIE Proceedings Vol. 2974:
Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin M.D., Editor(s)

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