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Proceedings Paper

Laser-initiated decomposition products of indocyanine green (ICG) and carbon black sensitized biological tissues
Author(s): John M. Kokosa; Andrzej Przyjazny; Kenneth Eugene Bartels; Massoud Motamedi; Donald J. Hayes; David B. Wallace; Christopher J. Frederickson
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Paper Abstract

Organic dyes have found increasing use a s sensitizers in laser surgical procedures, due to their high optical absorbances. Little is known, however, about the nature of the degradation products formed when these dyes are irradiated with a laser. Previous work in our laboratories has shown that irradiation of polymeric and biological tissues with CO2 and Nd:YAG lasers produces a host of volatile and semivolatile by-products, some of which are known to be potential carcinogens. This work focuses on the identification of the chemical by-products formed by diode laser and Nd:YAG laser irradiation of indocyanine green (ICG) and carbon black based ink sensitized tissues, including bone, tendon and sheep's teeth. Samples were mounted in a 0.5-L Pyrex sample chamber equipped with quartz optical windows, charcoal filtered air inlet and an outlet attached to an appropriate sample trap and a constant flow pump. By-products were analyzed by GC/MS and HPLC. Volatiles identified included benzene and formaldehyde. Semi-volatiles included traces of polycyclic aromatics, arising from the biological matrix and inks, as well as fragments of ICG and the carbon ink components. The significance of these results will be discussed, including the necessity of using appropriate evacuation devices when utilizing lasers for surgical procedures.

Paper Details

Date Published: 2 May 1997
PDF: 9 pages
Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); doi: 10.1117/12.275244
Show Author Affiliations
John M. Kokosa, GMI Engineering and Management Institute (United States)
Andrzej Przyjazny, GMI Engineering and Management Institute (United States)
Kenneth Eugene Bartels, Oklahoma State Univ. College of Veterinary Medicine (United States)
Massoud Motamedi, Univ. of Texas Medical Branch at Galveston (United States)
Donald J. Hayes, MicroFab Technologies, Inc. (United States)
David B. Wallace, MicroFab Technologies, Inc. (United States)
Christopher J. Frederickson, Univ. of Texas/Dallas (United States)

Published in SPIE Proceedings Vol. 2974:
Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin, Editor(s)

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