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Proceedings Paper

Treatment of laser-induced retinal injuries by neuroprotection
Author(s): Yoram Solberg; Mordechai Rosner; Michael Belkin
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Paper Abstract

Retinal laser photocoagulation treatments are often complicated with immediate side-effect of visual impairment. To determine whether glutamate-receptor blockers can serve as adjuvant neuroprotective therapy, we examined the effect of MK-801, an NMDA-receptor antagonist, on laser-induced retinal injury in a rat model. Argon laser retinal lesions were created in the retina of 36 DA rats. Treatment with intraperitoneal injections of MK-801 or saline was started immediately after the laser photocoagulation. The animals were sacrificed after 3, 20 or 60 days and the retinal lesions were evaluated histologically and morphometrically. Photoreceptor-cell loss was significantly smaller in MK-801-treated rats than controls. The proliferative membrane composed of retinal pigment epithelial cells which was seen at the base of the lesion in control retinas, was smaller in the MK-801-treated retinas. MK-801 exhibited neuroprotective and anti-proliferative properties in the retina. Glutamate-receptor blockers should be further investigated for serving as adjuvant therapy to retinal photocoagulation treatments.

Paper Details

Date Published: 2 May 1997
PDF: 8 pages
Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); doi: 10.1117/12.275238
Show Author Affiliations
Yoram Solberg, Tel Aviv Univ. Goldschleger Eye Research Institute (Israel)
Mordechai Rosner, Tel Aviv Univ. Goldschleger Eye Research Institute (Israel)
Michael Belkin, Tel Aviv Univ. Goldschleger Eye Research Institute (Israel)


Published in SPIE Proceedings Vol. 2974:
Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment
Bruce E. Stuck; Michael Belkin, Editor(s)

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