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Proceedings Paper

Posterior fixation keratoprostheses and mechanical biocompatibility: determination of critical intraocular pressure causing aqueous humor leak and/or keratoprosthesis extrusion
Author(s): Hassan Tahi; Bernard Duchesne; Jean-Marie A. Parel; Izuru Nose; David B. Denham; Franck L. Villain; Emmanuel Lacombe
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Paper Abstract

The effect of increased intraocular pressure (IOP) in human cadaver eyes implanted with posterior fixation keratoprosthesis was evaluated. Experiments were carried out with six fresh pairs of human cadaver eyes. One eye of each pair was implanted with a PCL-5 keratoprosthesis (8.60 mm diameter with an optic of 5.60 nm diameter) and the contralateral eye was used as a control. The keratoprosthesis was inserted through a 6 mm diameter opening trephined in the cornea. The resistance of the implanted eye to pressure on `aqueous humor' leak and/or keratoprosthesis extrusion was tested by infusing water at a constant flow of 60 mmHg/second into the anterior chamber. IOP variations were recorded with a transducer connected to a computer. IOP could be increased up to 1520 to 2324 mmHg before aqueous humor leaks occurred. Leaks were always located at the keratoprosthesis-cornea interface. No prosthesis extrusion was observed. Implanted eyes that did not leak aqueous and control eyes tore at the sclera. All posterior fixation keratoprostheses implanted eyes resisted more than 100 times the normal physiological intraocular pressure and on this standpoint is safe. Additional experiments were needed to assess the influence of suture fixation and wound healing in an animal model.

Paper Details

Date Published: 26 May 1997
PDF: 5 pages
Proc. SPIE 2971, Ophthalmic Technologies VII, (26 May 1997); doi: 10.1117/12.275109
Show Author Affiliations
Hassan Tahi, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (USA) and Univ. of Liege (Belgium)
Bernard Duchesne, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (USA) and Univ. of Liege (Belgium)
Jean-Marie A. Parel, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine and College of Engineering (United States)
Izuru Nose, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
David B. Denham, Bascom Palmer Eye Institute/Univ. of Miami School of Medicine (United States)
Franck L. Villain, Univ. of Miami College of Engineering (USA) and Corneal Industries SA (France)
Emmanuel Lacombe, Hopital de l'Hotel Dieu Univ. de Paris (France)


Published in SPIE Proceedings Vol. 2971:
Ophthalmic Technologies VII
Pascal O. Rol; Karen Margaret Joos; Fabrice Manns, Editor(s)

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