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Proceedings Paper

Laser-induced thermotherapy (LITT) for the treatment of liver metastases: the correlation of Gd-DTPA-enhanced magnetic resonance imaging (MRI) and histomorphological findings in the chronic model
Author(s): Christoph Martin Isbert; Christoph-Thomas Germer; Dirk Albrecht; Andreas Schilling; Antje Heiniche M.D.; Andre Roggan; Karl Juergen Wolf; Gerhard J. Mueller; Heinz-Johannes Buhr
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Paper Abstract

The purpose of the study was to evaluate Gd-DTPA-enhanced MRI for the follow-up of laser-induced thermotherapy (LITT) in the treatment of liver metastases. Interstitial laser-induced thermotherapy (LITT) was performed in 55 chinchilla bastard rabbits with a Nd:YAG laser and a specially developed diffuser tip applicator. The animals were examined at different times using MRI and histological methods. T1-weighted spin-echo sequences were made with gadolinium-DTPA and submitted to correlation analysis. The analysis yielded a good correlation (r equals 0.96) between the largest lesion diameters. Lesions showed discontinuous regeneration kinetics with a 41% volume reduction 1 month after LITT. MRI of the lesion directly after LITT showed a hyperintense transition zone. Following the application of intravenous contrast medium, transition zone enhancement was first seen 72 - 96 hours after LITT. Even after 6 months, the laser-induced lesion is visualized as a non-enhanced area. Lesion regeneration followed the principles of wound healing. It is concluded that gadolinium-DTPA- enhanced MRI yielded definitive criteria for the follow-up assessment of LITT.

Paper Details

Date Published: 22 May 1997
PDF: 11 pages
Proc. SPIE 2970, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII, (22 May 1997); doi: 10.1117/12.275089
Show Author Affiliations
Christoph Martin Isbert, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Christoph-Thomas Germer, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Dirk Albrecht, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Andreas Schilling, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Antje Heiniche M.D., Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Andre Roggan, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Karl Juergen Wolf, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Gerhard J. Mueller, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)
Heinz-Johannes Buhr, Benjamin Franklin Medical Ctr./Freie Univ. Berlin (Germany)


Published in SPIE Proceedings Vol. 2970:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII
R. Rox Anderson M.D.; Harvey Lui M.D.; Michail M. Pankratov; Kenneth Eugene Bartels D.V.M.; Gerhard J. Mueller; Graham M. Watson M.D.; Reza S. Malek M.D.; Lawrence S. Bass M.D.; Lloyd P. Tate V.D.M.; Hans-Dieter Reidenbach; Kenneth Eugene Bartels D.V.M.; R. Rox Anderson M.D.; Lawrence S. Bass M.D.; Aaron P. Perlmutter M.D.; Kenton W. Gregory M.D.; David M. Harris; David M. Harris; Harvey Lui M.D.; Reza S. Malek M.D.; Gerhard J. Mueller; Michail M. Pankratov; Aaron P. Perlmutter M.D.; Hans-Dieter Reidenbach; Lloyd P. Tate V.D.M.; Graham M. Watson M.D., Editor(s)

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